Elastic Changes in Chicken Blood Coagulation Activated by the Extrinsic Pathway

An alternative extrinsic pathway of human blood coagulation.

To study the interrelationships of the major human coagulation pathways, factor X activation in normal and various deficient human plasmas was evaluated when clotting was triggered by dilute rabbit or human thromboplastin. Various dilutions of thromboplastin were added to plasma samples containing 3H-labeled factor X, and the time course of factor X activation was determined. At a 1/250 dilutio...

Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis.

Hemostasis requires both platelets and the coagulation system. At sites of vessel injury, bleeding is minimized by the formation of a hemostatic plug consisting of platelets and fibrin. The traditional view of the regulation of blood coagulation is that the initiation phase is triggered by the extrinsic pathway, whereas amplification requires the intrinsic pathway. The extrinsic pathway consist...

Changes in blood coagulation.

Demonstration of the extrinsic coagulation pathway in teleostei: identification of zebrafish coagulation factor VII.

It is not known whether the mammalian mechanism of coagulation initiation is conserved in fish. Identification of factor VII is critical in providing evidence for such a mechanism. A cDNA was cloned from a zebrafish (teleost) library that predicted a protein with sequence similarity to human factor VII. Factor VII was shown to be present in zebrafish blood and liver by Western blot analysis and...

extrinsic and intrinsic coagulation pathway, fibrinogen serum level and platelet count in hiv positive patients.

infection with human immunodeficiency virus (hiv) is a progressive condition which may cause endothelial dysfunction and liver damage leading to coagulopathy. with adventure of highly active antiretroviral therapy (haart), life expectancy has prolonged in hiv positive patients but several acquired immunodeficiency syndrome (aids)-related conditions such as coagulopathies are responsible for ass...